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KMID : 1123920020160010133
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 1 p.133 ~ p.140
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Study on Anitmetastatic Effects of Antivascular-first
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Son Chang-Gue
Cho Chong-Kwan
Lee Seung-Ho
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Abstract
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To evaluate the anti metastatic effect of Antivascular-first(AntiV-F), we investigated cytotoxic effect on B16-F10 and HMCB. gene expression of MMP-9 and nm23-H1, and survival. After treating with AntiV-F, AntlV-F promoted cytotoxic effect on B16-F10 and HMCB as its density, compared with Control. AntiV-F inhibited gene expression of MMP-9 in the L+14 and HMCB cell line compared with Control. On the other hand AntiV-F increases gene expression of nm23-H1 and survival about 30% compared with Control. These results suggest that AntiV-F has effects on anti-metastasis can be used for treatment of cancer patients and preventing recurrence.
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KEYWORD
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antimetastatic effect, Antivascular-first(AntiV-F), MMP-9 and nm23-H1
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